James Rodriguez was sold to Everton in the summer, while Gareth Bale is currently spending the season on loan at Real Madrid.
And Isco could now be next.
Meanwhile, Gunners legend Kevin Campbell recently questioned their interest in Isco – and hailed Bakuyo Saka and Smith Rowe for their recent showings.
“Well Emile Smith Rowe’s been creative, Saka’s been creative. So I’m not sure where Isco would fit,” he said.
“He’s s a gifted player, don’t get me wrong, but he’s not someone who’ll pick the ball up and go past people. He’s a technical operator.